Lxxvii. the Unsaponifiable Fraction of Liver
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Uptake of triacylglycerol-rich lipoproteins of differing triacylglycerol molecular species and unsaponifiable content by liver cells.
The fatty acid composition of dietary oils can modulate the incorporation of triacylglycerol-rich lipoproteins (TRL) into hepatocytes, thus affecting the atherogenicity of these particles. However, nothing is known about the effect of the unsaponifiable fraction of the oils. In the present study, we evaluated the influence of these components on the uptake of TRL by rat primary hepatocytes. TRL...
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In 1952 Penn (21) described the preparation of an unsaponifiable fraction of liver from cancerbearing patients which gave a serological reaction with sera of cancerous individuals, but usually not with normal serum or serum from persons with noncancerous diseases (12). The difficulty of ob taining sufficient stable test material for extensive cancer screening tests led to the development of a s...
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The hypothesis that the unsaponifiable fraction of olive oil dramatically influences hepatic gene expression was tested in mice. Two olive oils, obtained from the same olive cultivar but by different technological procedures, were characterized to show that they differed mainly in terms of the composition/quantity of this unsaponifiable fraction. Using DNA microarrays, hepatic gene expression w...
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Lanosterol and related CzO sterols occur in considerable quantity in wool fat but have not so far been isolated from the principal sites of sterol biogenesis in the animal body. Evidence for the presence of this type of sterol in internal organs does, however, exist, since the formation of lanosterol from acetate and its conversion to cholesterol in homogenates of rat liver have recently been d...
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Evidence has been presented, in a preliminary communication from this laboratory (I), and by Schogt, Begemann, and Koster (2), to substantiate the previously postulated existence (3, 4) of nonphosphatide plasmalogens. This evidence was based mainly on observations made with unsaponifiable fractions obtained after treatment of neutral lipid with alkali. In our preliminary communication (I), for ...
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تاریخ انتشار 2005